SB-277011 dihydrochloride
SB-277011 dihydrochloride is a potent, selective, and brain-penetrant dopamine D3 receptor antagonist (pKi = 8.0), exhibiting >100-fold selectivity over D2 and serotonergic receptors. This tool compound is used in preclinical research to investigate D3 receptor function in models of addiction, Parkinson's disease, and schizophrenia in both in vitro and in vivo studies.
Product Specifications
CAS Number
1226917-67-4
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
N#CC1=CC=C (C (CC2) =C1) CN2CC[C@@H] (CC3) CC[C@H]3NC (C4=CC=NC5=C4C=CC=C5) =O.Cl.Cl
Molecular Formula
C28H32Cl2N4O
Molecular Weight
511.49
Storage Conditions
-20°C
Notes
For research use only.
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