SIAIS178
SIAIS178 is a potent and selective PROTAC molecule that targets BCR-ABL for degradation via recruitment of the VHL E3 ligase, with an IC50 of 24 nM. It demonstrates robust anti-proliferative activity in leukemia cell cultures and has been shown to induce regression in K562 xenograft tumor models in vivo.
Product Specifications
CAS Number
2376047-73-1
Product Name Alternative
BcrAbl, Bcr-Abl, SIAIS 178, SIAIS178, SIAIS-178, SIAI S178, VHL
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.07% (May vary between batches)
Solubility
DMSO:245 mg/mL (241.93 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.94 mM)
Smiles
C ([C@@H] (NC (CCCCCCC (=O) N1CCN (CC1) C=2C=C (NC=3SC (C (NC4=C (C) C=CC=C4Cl) =O) =CN3) N=C (C) N2) =O) [C@] (C) (C) C) (=O) N5[C@H] (C (NCC6=CC=C (C=C6) C7=C (C) N=CS7) =O) C[C@@H] (O) C5
Molecular Formula
C50H62ClN11O6S2
Molecular Weight
1012.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2479824 100 µL
Zeta Opioid Receptor Rabbit Polyclonal Antibody (BF555)
Sign In for Pricing
View Details 
orb2842883 100 µL
Phospho-E2F1 (Ser364) Rabbit pAb, IRDye 800CW conjugated
Sign In for Pricing
View Details