SIAIS178
SIAIS178 is a potent and selective PROTAC molecule that targets BCR-ABL for degradation via recruitment of the VHL E3 ligase, with an IC50 of 24 nM. It demonstrates robust anti-proliferative activity in leukemia cell cultures and has been shown to induce regression in K562 xenograft tumor models in vivo.
Product Specifications
CAS Number
2376047-73-1
Product Name Alternative
BcrAbl, Bcr-Abl, SIAIS 178, SIAIS178, SIAIS-178, SIAI S178, VHL
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.07% (May vary between batches)
Solubility
DMSO:245 mg/mL (241.93 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.94 mM)
Smiles
C ([C@@H] (NC (CCCCCCC (=O) N1CCN (CC1) C=2C=C (NC=3SC (C (NC4=C (C) C=CC=C4Cl) =O) =CN3) N=C (C) N2) =O) [C@] (C) (C) C) (=O) N5[C@H] (C (NCC6=CC=C (C=C6) C7=C (C) N=CS7) =O) C[C@@H] (O) C5
Molecular Formula
C50H62ClN11O6S2
Molecular Weight
1012.68
Storage Conditions
-20°C
Notes
For research use only.
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