Sulindac sulfide
Sulindac sulfide, the active metabolite of sulindac, is a potent COX-1 inhibitor and non-competitive gamma-secretase inhibitor (IC50 = 20.2 μM) . It is widely used in research on inflammation, cancer (notably colorectal), and Alzheimer's disease, employing both in vitro and in vivo models to study Ras/Raf signaling and amyloid precursor protein processing.
Product Specifications
CAS Number
49627-27-2
Product Name Alternative
γ42-secretase, Raf-1, mAChR, cis-Sulindac sulfide
Field of Research
Cell Biology
Purity
>98%
Bioactivity
NFkB inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) .
Smiles
C (=C/1\C=2C (C (CC (O) =O) =C1C) =CC (F) =CC2) \C3=CC=C (SC) C=C3
Molecular Formula
C20H17FO2S
Molecular Weight
340.42
Storage Conditions
RT
Notes
For research use only.
Other Product Names
(Z) -5-Fluoro-2-methyl-1-[p- (methylthio) benzylidene]indene-3-acetic acid
Available Sizes
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