BCX 1470 methanesulfonate

BCX 1470 methanesulfonate is a potent and selective inhibitor of the serine proteases factor D and C1s, with IC50 values of 96 nM and 1.6 nM, respectively. It demonstrates significantly greater potency against these complement system enzymes than against trypsin. This inhibitor is a valuable research tool for studying the classical and alternative complement pathways in both in vitro and in vivo experimental models.