AZD0156
Product Specifications
UNSPSC Description
AZD0156 is a potent, selective and orally active ATM inhibitor with an IC50 of 0.58 nM. AZD0156 inhibits the ATM-mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis[1].
Target Antigen
Apoptosis; ATM/ATR
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD0156.html
Purity
99.83
Smiles
O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3
Molecular Weight
461.56
References & Citations
[1]Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer.?
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100016/AZD0156-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100016/AZD0156-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
1821428-35-6
Available Sizes
Curated Selection
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