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Homocarbonyltopsentin

Homocarbonyltopsentin is a small molecule that binds the TSL2 RNA pentaloop, shifting its conformation to a triloop. This structural change enhances SMN2 exon 7 splicing with an EC50 of 16 μM, making it a valuable research tool for studying spinal muscular atrophy (SMA) therapeutics in vitro.

Product Specifications

CAS Number

172286-77-0

Field of Research

Cell Biology, Molecular Biology

Smiles

Oc1ccc2c (c[nH]c2c1) C (=O) c1ncc ([nH]1) C (=O) c1c[nH]c2ccccc12

Molecular Formula

C21H14N4O3

Molecular Weight

370.36

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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