Homocarbonyltopsentin
Homocarbonyltopsentin is a small molecule that binds the TSL2 RNA pentaloop, shifting its conformation to a triloop. This structural change enhances SMN2 exon 7 splicing with an EC50 of 16 μM, making it a valuable research tool for studying spinal muscular atrophy (SMA) therapeutics in vitro.
Product Specifications
CAS Number
172286-77-0
Field of Research
Cell Biology, Molecular Biology
Smiles
Oc1ccc2c (c[nH]c2c1) C (=O) c1ncc ([nH]1) C (=O) c1c[nH]c2ccccc12
Molecular Formula
C21H14N4O3
Molecular Weight
370.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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