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PROTAC SGK3 degrader-1

SGK3-PROTAC1 is a heterobifunctional degrader that recruits the VHL E3 ligase to SGK3, leading to its proteasomal degradation. This compound, CAS 5017-88-83-4, has been shown to inhibit cancer cell proliferation in vitro, including countering GDC0941-induced proliferation, making it a valuable tool for studying SGK3 biology in oncology research.

Product Specifications

CAS Number

2381320-35-8

Field of Research

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Smiles

Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) COCCOCCOCCCCCCN2CCO[C@@H] (COc3nc (nc4[nH]ncc34) -c3ccc (NS (=O) (=O) c4cc (C) ccc4F) cc3) C2) C (C) (C) C) cc1

Molecular Formula

C57H73FN10O11S2

Molecular Weight

1157.38

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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