(S, R, S) -AHPC-propargyl
(S, R, S) -AHPC-propargyl is a von Hippel-Lindau (VHL) E3 ligase ligand functionalized with a propargyl group. This chemical handle enables its use in copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry for the efficient synthesis of PROTACs, facilitating targeted protein degradation research in both cellular and in vivo models.
Product Specifications
CAS Number
2098799-78-9
Field of Research
Pharmacology & Drug Discovery
Smiles
C ([C@@H] (NC (COCC#C) =O) [C@@] (C) (C) C) (=O) N1[C@H] (C (NCC2=CC=C (C=C2) C3=C (C) N=CS3) =O) C[C@@H] (O) C1
Molecular Formula
C27H34N4O5S
Molecular Weight
526.65
Storage Conditions
-20°C
Notes
For research use only.
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