TL13-112
TL13-112 is a potent and selective ALK-PROTAC degrader, demonstrating high inhibitory activity with an IC50 of 0.14 nM. This compound is a valuable chemical tool for investigating ALK-dependent signaling in cancer research, applicable in both cellular and in vivo preclinical studies.
Product Specifications
CAS Number
2229037-19-6
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1C=2C=CC=C (NCC (=O) NCCOCCOCCN3CCC (C4=CC (OC (C) C) =C (C=C4C) NC5=NC=C (Cl) C (=N5) NC=6C=CC=CC6S (=O) (=O) C (C) C) CC3) C2C (=O) N1C7C (=O) NC (=O) CC7
Molecular Formula
C49H60ClN9O10S
Molecular Weight
1002.57
Storage Conditions
-20°C
Notes
For research use only.
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