AGI-24512
AGI-24512 is a potent and selective MAT2A inhibitor (IC50: 8 nM) with antiproliferative effects in MTAP-deficient cancer cells. Its mechanism, which induces DNA damage, supports its use in both in vitro and in vivo studies exploring novel combination therapies for oncology research.
Product Specifications
CAS Number
2201066-53-5
Product Name Alternative
S-adenosylmethionine Synthetase, PRMT5, HCT116, MAT2A, MATA2, MTAP, methylthioadenosine phosphorylase, Methionine Adenosyltransferase (MAT), anticancer, antiproliferative, AGI 24512, AGI24512, AGI-24512, DNA damage response, DNA
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
98.55% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.24 mM) ; DMSO:80 mg/mL (199.77 mM) ; H2O:< 0.1 mg/mL (insoluble)
Smiles
Cc1[nH]c2c (N3CCCCC3) c (nn2c (=O) c1-c1ccc (O) cc1) -c1ccccc1
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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