AMG-1694
AMG-1694 is a potent small molecule disruptor of the GK-GKRP complex with an IC50 of 7 nM. It indirectly activates glucokinase, reverses GKRP-mediated inhibition, and promotes GK translocation. This compound effectively normalizes blood glucose in diabetic rodent models without inducing hypoglycemia in normoglycemic animals, making it a valuable research tool for studying type 2 diabetes pathways.
Product Specifications
CAS Number
1361217-07-3
Product Name Alternative
AMG1694, AMG-1694, AMG 1694, GK-GKRP
Field of Research
Metabolism Research
Purity
97.94% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.75 mM) ; DMSO:50 mg/mL (93.7 mM)
Smiles
C ([C@@H]1N (CCN (S (=O) (=O) C2=CC=CS2) C1) C3=CC=C ([C@@] (C (F) (F) F) (C) O) C=C3) N4[C@@H] (C) COCC4
Molecular Formula
C23H30F3N3O4S2
Molecular Weight
533.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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