JWG-071
JWG-071 is the first reported chemical probe demonstrating selectivity for ERK5 kinase. It functions as a BET-selective inhibitor with a 1 μM IC50 for BRD4, paradoxically enhancing ERK5 activity. This probe is used in vitro to study kinase signaling crosstalk and BET bromodomain biology in cancer research.
Product Specifications
CAS Number
2250323-50-1
Product Name Alternative
ERK5, EpigeneticReaderDomain, Epigenetic Reader Domain, JWG 071, JWG071, JWG-071, BRD4
Field of Research
Epigenetics & Chromatin, Signal Transduction
Purity
98.33% (May vary between batches)
Solubility
DMSO:61.28 mg/mL (100 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.26 mM)
Smiles
CCC (C) N1c2ccccc2C (=O) N (C) c2cnc (Nc3ccc (cc3OC) C (=O) N3CCC (CC3) N3CCN (C) CC3) nc12
Molecular Formula
C34H44N8O3
Molecular Weight
612.77
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1065631-01 0.02 mg (E-Coli)
Recombinant Haemophilus influenzae Integration host factor subunit alpha (ihfA)
Sign In for Pricing
View Details MBS1065631-02 0.1 mg (E-Coli)
Recombinant Haemophilus influenzae Integration host factor subunit alpha (ihfA)
Sign In for Pricing
View Details MBS1065631-03 0.02 mg (Yeast)
Recombinant Haemophilus influenzae Integration host factor subunit alpha (ihfA)
Sign In for Pricing
View Details MBS1065631-04 0.1 mg (Yeast)
Recombinant Haemophilus influenzae Integration host factor subunit alpha (ihfA)
Sign In for Pricing
View Details MBS1065631-05 0.02 mg (Baculovirus)
Recombinant Haemophilus influenzae Integration host factor subunit alpha (ihfA)
Sign In for Pricing
View Details MBS1065631-06 1 mg (E-Coli)
Recombinant Haemophilus influenzae Integration host factor subunit alpha (ihfA)
Sign In for Pricing
View Details