BI-0252
BI-0252 is a potent and selective MDM2-p53 interaction inhibitor with an IC50 of 4 nM. It demonstrates robust in vivo efficacy, inducing complete tumor regression in SJSA-1 xenograft models, which is associated with activation of p53 target genes and apoptotic markers. This molecule is a valuable chemical probe for researching p53 pathway biology in cancer models both in vitro and in vivo.
Product Specifications
CAS Number
1818291-27-8
Field of Research
Cell Biology, Protein Biochemistry
Smiles
C (N1[C@@]2 ([C@H] ([C@]3 ([C@@]1 (C[C@@H] (N3) C4=CC=C (C (O) =O) C=C4) [H]) [H]) C5=C (F) C (Cl) =CC=C5) C=6C (NC2=O) =CC (Cl) =CC6) C7CC7
Molecular Formula
C30H26Cl2FN3O3
Molecular Weight
566.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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