BIIE-0246
BIIE-0246 is a potent and selective antagonist of the NPY Y2 receptor, exhibiting an IC50 of 15 nM in rat binding assays. It effectively inhibits NPY-induced phosphorylation of AKT and MAPK signaling pathways, making it a valuable tool for investigating metabolic and neurological functions in both cellular and animal models.
Product Specifications
CAS Number
246146-55-4
Product Name Alternative
AR-H 053591, AR-H053591, AR-H-053591, BIIE 0246, BIIE0246, BIIE-0246, NPYY2 receptor, plusmn
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.03% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (3.68 mM) ; DMSO:≥ 80 mg/mL
Smiles
O=C1C=2C (C (C=3C (N1) =CC=CC3) N4CCN (C (CC5 (CC (N[C@H] (C (NCCN6C (=O) N (N (C6=O) C7=CC=CC=C7) C8=CC=CC=C8) =O) CCCNC (=N) N) =O) CCCC5) =O) CC4) =CC=CC2
Molecular Formula
C49H57N11O6
Molecular Weight
896.05
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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