BMS 299897
BMS 299897 is a potent sulfonamide γ-secretase inhibitor that effectively reduces Aβ peptide production, demonstrating an IC50 of 7 nM in APP-overexpressing HEK293 cells. This compound is a valuable research tool for investigating Alzheimer's disease pathogenesis in both cellular and animal models, targeting the amyloidogenic processing pathway.
Product Specifications
CAS Number
290315-45-6
Product Name Alternative
Gammasecretase, BetaAmyloid, Beta Amyloid, BMS299897, BMS-299897, BMS 299897, Aβ, b Amyloid, bAmyloid, βAmyloid, β Amyloid, γ-secretase
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
99.82% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.91 mM) ; DMSO:27 mg/mL (52.74 mM)
Smiles
C[C@@H] (N (c1cc (F) ccc1F) S (=O) (=O) c1ccc (Cl) cc1) c1ccc (F) cc1CCCC (O) =O
Molecular Formula
C24H21ClF3NO4S
Molecular Weight
511.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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