BMS-509744
BMS-509744 is a potent and selective ATP-competitive inhibitor of interleukin-2-inducible T-cell kinase (Itk), exhibiting an IC50 of 19 nM. It has demonstrated efficacy in reducing IL-8 expression and HIV infection in vitro, as well as ameliorating pulmonary inflammation in allergic asthma and Imiquimod-induced skin inflammation in murine models.
Product Specifications
CAS Number
439575-02-7
Product Name Alternative
BMS 509744, BMS509744, BMS-509744, Itk
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry, Signal Transduction
Purity
99.70% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (4.01 mM) ; DMSO:52 mg/mL (83.36 mM)
Smiles
O=C (NC1=NC=C (S1) SC2=CC (=C (OC) C=C2C) C (=O) N3CCN (C (=O) C) CC3) C4=CC=C (C=C4) CNC (C) C (C) (C) C
Molecular Formula
C32H41N5O4S2
Molecular Weight
623.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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