BMS-690514
BMS-690514 is an orally bioavailable small molecule that potently inhibits EGFR, VEGFR, and HER family kinases, with IC50 values of 5 nM (EGFR), 20 nM (HER2), and 60 nM (HER4) . It has been utilized in preclinical cancer research to study angiogenesis and tumor growth inhibition in both cellular assays and animal models.
Product Specifications
CAS Number
859853-30-8
Product Name Alternative
BMS 690514, BMS690514, BMS-690514, inhibit, Inhibitor, HER2, HER4, HER1, Epidermal growth factor receptor, ErbB-1, EGFR, Vascular endothelial growth factor receptor, VEGFR
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.08% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.43 mM) ; DMSO:24 mg/mL (65.14 mM)
Smiles
COc1cccc (Nc2ncnn3ccc (CN4CC[C@@H] (N) [C@H] (O) C4) c23) c1
Molecular Formula
C19H24N6O2
Molecular Weight
368.43
Storage Conditions
-20°C
Notes
For research use only.
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