GW-406381
GW-406381 is a highly selective COX-2 inhibitor that acts both peripherally and centrally. It has been shown to reduce spontaneous ectopic discharges in the rat gastrocnemius nerve following chronic constriction injury, making it a useful tool for studying central sensitization and inflammatory pain mechanisms in preclinical models.
Product Specifications
CAS Number
221148-46-5
Product Name Alternative
COX-2, GW406381, GW-406381, GW 406381
Field of Research
Immunology & Inflammation, Neuroscience
Purity
99.54% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (8.39 mM) ; DMSO:80 mg/mL (203.32 mM)
Smiles
CCOc1ccc (cc1) -c1nn2ncccc2c1-c1ccc (cc1) S (C) (=O) =O
Molecular Formula
C21H19N3O3S
Molecular Weight
393.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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