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IN-1130

IN-1130 is a potent and selective ALK5 inhibitor, demonstrating IC50 values of 5.3 nM for ALK5-mediated Smad3 phosphorylation, 36 nM for casein phosphorylation, and 4.3 μM for p38α MAPK. This small molecule is a valuable research tool for investigating TGF-β signaling pathways in both cellular and animal models of fibrosis and cancer.

Product Specifications

CAS Number

868612-83-3

Product Name Alternative

IN 1130, IN1130, IN-1130, ALK5

Field of Research

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.08% (May vary between batches)

Solubility

DMSO:90 mg/mL (214.05 mM) ;10% DMSO+90% Saline:1 mg/mL (2.38 mM)

Smiles

Cc1cccc (n1) -c1nc (Cc2cccc (c2) C (N) =O) [nH]c1-c1ccc2nccnc2c1

Molecular Formula

C25H20N6O

Molecular Weight

420.47

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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