IN-1130
IN-1130 is a potent and selective ALK5 inhibitor, demonstrating IC50 values of 5.3 nM for ALK5-mediated Smad3 phosphorylation, 36 nM for casein phosphorylation, and 4.3 μM for p38α MAPK. This small molecule is a valuable research tool for investigating TGF-β signaling pathways in both cellular and animal models of fibrosis and cancer.
Product Specifications
CAS Number
868612-83-3
Product Name Alternative
IN 1130, IN1130, IN-1130, ALK5
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.08% (May vary between batches)
Solubility
DMSO:90 mg/mL (214.05 mM) ;10% DMSO+90% Saline:1 mg/mL (2.38 mM)
Smiles
Cc1cccc (n1) -c1nc (Cc2cccc (c2) C (N) =O) [nH]c1-c1ccc2nccnc2c1
Molecular Formula
C25H20N6O
Molecular Weight
420.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TL702736V 500 µL Each
Dcun1d3 Rat shRNA Lentiviral Particle (Locus ID 309035)
Sign In for Pricing
View Details 
bs-5089R-BF647 100 µL
OXCT1 Polyclonal Antibody, AbBy Fluor™ 647 Conjugated
Sign In for Pricing
View Details 