ITX3
ITX3 is a potent and selective inhibitor of the TrioN RhoGEF domain, exhibiting an IC50 of 76 μM. It effectively blocks Trio-mediated activation of RhoG and Rac1 GTPases, which underlies its utility in studying cell morphology, neurite outgrowth in PC12 cells, and fibroblast structural changes in vitro.
Product Specifications
CAS Number
347323-96-0
Product Name Alternative
ITX 3, ITX3, ITX-3, Rho GEFs
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.28% (May vary between batches)
Solubility
DMSO:4 mg/mL (10.77 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1cc (\C=c2\sc3nc4ccccc4n3c2=O) c (C) n1-c1ccccc1
Molecular Formula
C22H17N3OS
Molecular Weight
371.45
Storage Conditions
-20°C
Notes
For research use only.
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