JNJ-54175446
JNJ-54175446 is a brain-penetrant, selective P2X7 receptor antagonist that inhibits microglial release of pro-inflammatory cytokines IL-1β and IL-18. It is a valuable research tool for investigating neuroinflammation in depression models, with applications in both in vitro cellular assays and in vivo behavioral studies.
Product Specifications
CAS Number
1627902-21-9
Product Name Alternative
HP2X7 receptor, P2X Receptor, P2X7, P2XReceptor, JNJ54175446, JNJ-54175446, JNJ-5446, JNJ 54175446, rP2X7 receptor
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
97.98% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.54 mM) ; DMSO:50 mg/mL (113.44 mM)
Smiles
C[C@H]1N (CCc2c1nnn2-c1ncc (F) cn1) C (=O) c1cccc (c1Cl) C (F) (F) F
Molecular Formula
C18H13ClF4N6O
Molecular Weight
440.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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