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KIRA-7

KIRA-7 is an imidazopyrazine small molecule that acts as an allosteric inhibitor of IRE1α RNase activity by binding its kinase domain (IC50: 110 nM) . It exhibits anti-fibrotic properties and is utilized in research exploring endoplasmic reticulum stress in models of fibrotic disease, both in vitro and in vivo.

Product Specifications

CAS Number

1937235-76-1

Field of Research

Cell Biology

Smiles

CC1 (CC1) c1nc (-c2ccc (NC (=O) Nc3cccc (F) c3) c3ccccc23) c2c (N) nccn12

Molecular Formula

C27H23FN6O

Molecular Weight

466.51

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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