Lapaquistat acetate
Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor investigated for hypercholesterolemia research. It demonstrates anti-inflammatory properties and has been shown in vitro to reduce statin-induced toxicity in human muscle cells, as well as in vivo to protect guinea pigs from simvastatin-induced myotoxicity.
Product Specifications
CAS Number
189060-13-7
Product Name Alternative
TAK475, TAK-475, TAK 475, Squalene synthase
Field of Research
Metabolism Research
Purity
99.38% (May vary between batches)
Solubility
DMSO:1 mg/mL (1.55 mM)
Smiles
O (C) C1=C ([C@@H]2C=3C (N (CC (COC (C) =O) (C) C) C (=O) [C@@H] (CC (=O) N4CCC (CC (O) =O) CC4) O2) =CC=C (Cl) C3) C=CC=C1OC
Molecular Formula
C33H41ClN2O9
Molecular Weight
645.14
Storage Conditions
-20°C
Notes
For research use only.
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