Ribociclib hydrochloride
Ribociclib hydrochloride (LEE011 HCl) is an orally bioavailable, potent CDK4/6 inhibitor with IC50 values of 10 and 39 nM, respectively. It arrests the cell cycle in G1 phase and is widely used in cancer research, including in vitro proliferation assays and in vivo xenograft studies for breast cancer and other malignancies.
Product Specifications
CAS Number
1211443-80-9
Product Name Alternative
CDK4, CDK6, LEE011 hydrochloride, LEE-011 Hydrochloride, LEE 011 hydrochloride, Ribociclib Hydrochloride
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
99.87% (May vary between batches)
Solubility
H2O:8 mg/mL (16.99 mM) ; DMSO:5.8 mg/mL (12.31 mM)
Smiles
Cl.O=C (C1=CC=2C=NC (=NC2N1C3CCCC3) NC4=NC=C (C=C4) N5CCNCC5) N (C) C
Molecular Formula
C23H31ClN8O
Molecular Weight
471
Storage Conditions
-20°C
Notes
For research use only.
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