Lometrexol
Lometrexol (LY 264618) is an antipurine antifolate that potently inhibits glycinamide ribonucleotide formyltransferase (GARFT) and human serine hydroxymethyltransferase (hSHMT1/2), disrupting de novo purine synthesis. This activity leads to suppressed cell proliferation, cell cycle arrest, and apoptosis, underpinning its research use as an anticancer agent in both in vitro and in vivo studies.
Product Specifications
CAS Number
106400-81-1
Product Name Alternative
LY264618, LY-264618, LY 264618, Lometrexol, GARFT, DDATHF, Antifolate
Field of Research
Cell Biology, Metabolism Research, Molecular Biology, Protein Biochemistry
Purity
97.76% (May vary between batches)
Solubility
5% DMSO+40% PEG300+5% Tween 80+50% Saline:5 mg/mL (11.28 mM) ; DMSO:100 mg/mL (225.5 mM)
Smiles
Nc1nc2NC[C@H] (CCc3ccc (cc3) C (=O) N[C@@H] (CCC (O) =O) C (O) =O) Cc2c (=O) [nH]1
Molecular Formula
C21H25N5O6
Molecular Weight
443.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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