Marizomib
Marizomib is a brain-penetrant, irreversible proteasome inhibitor that potently targets the β5 (IC50=3.5 nM), β1 (28 nM), and β2 (430 nM) subunits of the 20S proteasome. It is widely used in preclinical research, including in vitro cell studies and in vivo models, for investigating cancer, neurodegenerative diseases, and proteasome biology.
Product Specifications
CAS Number
437742-34-2
Product Name Alternative
Salinosporamide A, trypsin-like, CT-T-laspase-like, CT-L, 20S proteasome, Marizomib, NPI 0052, NPI0052, NPI-0052, ML858, ML-858, ML 858
Field of Research
Protein Biochemistry
Purity
98.03% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.37 mM) ; DMSO:31.38 mg/mL (100.01 mM)
Smiles
[C@@H] (O) ([C@]12[C@] (C) ([C@@H] (CCCl) C (=O) N1) OC2=O) [C@]3 (CCCC=C3) [H]
Molecular Formula
C15H20ClNO4
Molecular Weight
313.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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