CLZ-8
CLZ-8 (Mcl1-IN-8) is an orally bioavailable, radioprotective small molecule that inhibits the Mcl-1/PUMA interaction. It mitigates radiation-induced apoptosis and cellular damage in HUVECs in vitro by suppressing PUMA overexpression, showing potential for research in radiation biology and apoptosis signaling pathways.
Product Specifications
CAS Number
678158-55-9
Product Name Alternative
CLZ 8, CLZ8, Mcl-1, Mcl1 IN 8, Mcl1IN8, Mcl-1-IN-8, Mcl1-IN-8
Field of Research
Cell Biology
Purity
99.85% (May vary between batches)
Solubility
DMSO:40 mg/mL (101.65 mM) ;10% DMSO+90% Corn Oil:1 mg/mL (2.54 mM)
Smiles
OCCN1CCN (CC1) C1=NC (=O) \C (S1) =C\c1ccc (cc1) -c1ccccc1
Molecular Formula
C22H23N3O2S
Molecular Weight
393.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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