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CLZ-8

CLZ-8 (Mcl1-IN-8) is an orally bioavailable, radioprotective small molecule that inhibits the Mcl-1/PUMA interaction. It mitigates radiation-induced apoptosis and cellular damage in HUVECs in vitro by suppressing PUMA overexpression, showing potential for research in radiation biology and apoptosis signaling pathways.

Product Specifications

CAS Number

678158-55-9

Product Name Alternative

CLZ 8, CLZ8, Mcl-1, Mcl1 IN 8, Mcl1IN8, Mcl-1-IN-8, Mcl1-IN-8

Field of Research

Cell Biology

Purity

99.85% (May vary between batches)

Solubility

DMSO:40 mg/mL (101.65 mM) ;10% DMSO+90% Corn Oil:1 mg/mL (2.54 mM)

Smiles

OCCN1CCN (CC1) C1=NC (=O) \C (S1) =C\c1ccc (cc1) -c1ccccc1

Molecular Formula

C22H23N3O2S

Molecular Weight

393.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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