ML224
ML224 (NCGC00242364) is a small molecule antagonist of the thyroid-stimulating hormone receptor (TSHR) . It is a research tool for investigating Graves' disease pathologies, including hyperthyroidism and orbitopathy, with demonstrated activity in both in vitro assays and in vivo animal models.
Product Specifications
CAS Number
1338824-21-7
Product Name Alternative
ANTAG 3, ANTAG3, ANTAG-3, ML224, ML-224, ML 224, NCGC 00242364, NCGC00242364, NCGC-00242364, thyrotropin receptor (TSHR), TSH Receptor, TSHReceptor
Field of Research
Pharmacology & Drug Discovery
Purity
99.14% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.28 mM) ; DMSO:80 mg/mL (152.21 mM)
Smiles
COc1ccc (cc1COc1c (C) cc (NC (C) =O) cc1C) C1Nc2ccccc2C (=O) N1Cc1ccco1
Molecular Formula
C31H31N3O5
Molecular Weight
525.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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