MSN-125
MSN-125 is a cell-permeable small molecule inhibitor of Bax/Bak oligomerization, thereby blocking mitochondrial outer membrane permeabilization (MOMP) and apoptosis. With an IC50 of 4 μM for MOMP inhibition, it has demonstrated protective effects against apoptotic cell death in HCT-116 cells, BMK cells, and primary cortical neurons, including in models of glutamate excitotoxicity.
Product Specifications
CAS Number
1592908-16-1
Field of Research
Cell Biology, Signal Transduction
Smiles
COCCOCOc1ccc2[C@@H] ([C@@H] (CN) Oc2c1) N (Cc1ccc (Br) cc1) C (=O) [C@H] (Cc1ccccc1) NC (=O) c1ccccc1
Molecular Formula
C36H38BrN3O6
Molecular Weight
688.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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