Nigericin
Nigericin is a polyether antibiotic with broad bioactivity, including antimicrobial, antimalarial, and anticancer properties. Its research applications involve studying ionophore-induced cell death mechanisms, such as pyroptosis and apoptosis via Caspase activation, in models like triple-negative breast cancer and primary effusion lymphoma, both in vitro and in vivo.
Product Specifications
CAS Number
28380-24-7
Product Name Alternative
K+/H+ ionophore, Nigericin
Field of Research
Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.50% (May vary between batches)
Solubility
Ethanol:45.91 mg/mL (63.33 mM) ; DMSO:5 mg/mL (6.9 mM)
Smiles
C[C@H]1[C@]2 (O[C@@] (C) (C1) [C@@]3 (O[C@@] (C) (CC3) [C@@]4 (O[C@] (C[C@@H]4C) ([C@]5 (O[C@] (CO) (O) [C@H] (C) C[C@@H]5C) [H]) [H]) [H]) [H]) O[C@H] (C[C@@H]6O[C@@] ([C@H] (C (O) =O) C) ([C@@H] (C) CC6) [H]) C[C@@H] (OC) [C@H]2C
Molecular Formula
C40H68O11
Molecular Weight
724.96
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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