PD 407824
PD 407824 is a BMP sensitizer that enhances cellular response to low-dose BMP4. It functions as a potent dual inhibitor of Chk1 and WEE1 kinases (IC50s: 47 and 97 nM) . This compound is used in vitro to study DNA damage checkpoint bypass, stem cell differentiation, and cancer cell sensitization in research.
Product Specifications
CAS Number
622864-54-4
Product Name Alternative
Chk1, PD 407824, PD407824, PD-407824, Wee1, WEE1
Field of Research
Cell Biology
Purity
98.02% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.18 mM) ; DMSO:100 mg/mL (304.58 mM)
Smiles
Oc1ccc2[nH]c3cc (c4C (=O) NC (=O) c4c3c2c1) -c1ccccc1
Molecular Formula
C20H12N2O3
Molecular Weight
328.32
Storage Conditions
-20°C
Notes
For research use only.
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