CUR61414
CUR61414 is a potent and cell-permeable smoothened (SMO) antagonist with a Ki of 44 nM, inhibiting the Hedgehog signaling pathway with an IC50 of 100-200 nM. This small molecule inhibitor is a valuable tool for probing Hh pathway biology in both cellular assays and in vivo disease models, including cancer research.
Product Specifications
CAS Number
334998-36-6
Product Name Alternative
Smoothened, Hedgehog inhibitor, Hedgehog, CUR 61414, CUR61414, CUR-61414
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Hedgehog pathway antagonist
Form
Powder
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml) .
Smiles
COc1cccc (CN ([C@H]2C[C@H] (N (Cc3ccc4OCOc4c3) C2) C (=O) N2CCNCC2) C (=O) CC (C) (C) C) c1
Molecular Formula
C31H42N4O5
Molecular Weight
550.71
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[ (3S,5S) -1- (1,3-Benzodioxol-5-ylmethyl) -5- (1-piperazinylcarbonyl) -3-pyrrolidinyl]-N-[ (3-methoxyphenyl) methyl]-3,3-dimethylbutanamide
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