DSM265
DSM265 is a potent and selective inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (DHODH), exhibiting antimalarial activity with an IC50 of 8.9 nM against Pf3D7 strains. It has demonstrated efficacy in both in vitro parasite growth assays and in vivo models for the treatment and prophylaxis of malaria.
Product Specifications
CAS Number
1282041-94-4
Product Name Alternative
DHODH, DSM 265, DSM265, DSM-265, PfDHODH, PfSPZ, P. falciparum 3D7 parasites, P. falciparum
Field of Research
Infectious Disease & Virology, Metabolism Research
Purity
99.79% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.82 mM) ; H2O:< 0.1 mg/mL (insoluble.) ; DMSO:30 mg/mL (72.23 mM) ; Ethanol:5 mg/mL (12.04 mM)
Smiles
Cc1cc (Nc2ccc (cc2) S (F) (F) (F) (F) F) n2nc (nc2n1) C (C) (F) F
Molecular Formula
C14H12F7N5S
Molecular Weight
415.33
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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