FMK 9a
FMK-9a is a potent and irreversible inhibitor of ATG4B, demonstrating IC50 values of 80 nM and 73 nM in TR-FRET and cellular luciferase reporter assays, respectively. This compound is a valuable chemical tool for investigating autophagy mechanisms in both in vitro and in vivo cancer research contexts.
Product Specifications
CAS Number
1955550-51-2
Product Name Alternative
Inhibitor, FMK 9a, inhibit, Autophagy, ATG4B, autophagin-1, FRET assay, autophagin-1, LRA assay, CysteineProtease, Cysteine Protease
Field of Research
Cell Biology, Protein Biochemistry
Purity
98.97% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.41 mM) ; DMSO:95 mg/mL (242.09 mM)
Smiles
FCC (=O) CNC (=O) [C@H] (Cc1ccccc1) NC (=O) c1cccc2ccccc12
Molecular Formula
C23H21FN2O3
Molecular Weight
392.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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