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GNE-207

GNE-207 is a potent, selective, and orally bioavailable CBP bromodomain inhibitor with an IC50 of 1 nM, demonstrating >2500-fold selectivity over BRD4. It effectively reduces MYC expression in MV-4-11 cells (EC50 = 18 nM) and is a valuable chemical probe for studying CBP/EP300 biology in cancer and other disease research.

Product Specifications

CAS Number

2158266-58-9

Field of Research

Epigenetics & Chromatin

Smiles

CNC (=O) c1ccc (cn1) -c1cc2cccc (-c3nn (C4CCOCC4) c4CCN (Cc34) C (C) =O) c2cn1

Molecular Formula

C29H30N6O3

Molecular Weight

510.59

Storage Conditions

-20°C

Notes

For research use only.

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