GNE-207
GNE-207 is a potent, selective, and orally bioavailable CBP bromodomain inhibitor with an IC50 of 1 nM, demonstrating >2500-fold selectivity over BRD4. It effectively reduces MYC expression in MV-4-11 cells (EC50 = 18 nM) and is a valuable chemical probe for studying CBP/EP300 biology in cancer and other disease research.
Product Specifications
CAS Number
2158266-58-9
Field of Research
Epigenetics & Chromatin
Smiles
CNC (=O) c1ccc (cn1) -c1cc2cccc (-c3nn (C4CCOCC4) c4CCN (Cc34) C (C) =O) c2cn1
Molecular Formula
C29H30N6O3
Molecular Weight
510.59
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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