GNE-0723
GNE-0723 is a brain-penetrant, selective positive allosteric modulator of GluN2A-containing NMDA receptors (EC50 = 21 nM) . It has demonstrated therapeutic potential in preclinical research, showing efficacy in improving cognitive and behavioral outcomes in models of Dravet syndrome and Alzheimer's disease.
Product Specifications
CAS Number
1883518-31-7
Product Name Alternative
GluN2C, GluN2D, GluN2A, GNE0723, GNE-0723, GNE 0723
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
97.29% (May vary between batches)
Solubility
DMSO:160 mg/mL (342.04 mM)
Smiles
C (F) (F) (F) C1=C (N2C (S1) =NC (CN3N=C (C (F) (F) F) C=C3Cl) =CC2=O) [C@H]4[C@H] (C#N) C4
Molecular Formula
C16H8ClF6N5OS
Molecular Weight
467.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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