PF-04447943
PF-04447943 (Edelinontrine) is a potent and selective PDE9A inhibitor (IC50=12 nM) demonstrating anti-inflammatory effects through modulation of oxidative stress and T-cell responses. It has shown potential in preclinical research for conditions like sickle cell disease, with studies conducted both in vitro and in vivo.
Product Specifications
CAS Number
1082744-20-4
Product Name Alternative
PDE9A, PF 04447943, PF04447943, PF-04447943, Edelinontrine
Field of Research
Metabolism Research
Purity
97.01% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (6.32 mM) ; DMSO:55 mg/mL (139.08 mM)
Smiles
C[C@@H]1CN (Cc2ncccn2) C[C@H]1c1nc2n (ncc2c (=O) [nH]1) C1CCOCC1
Molecular Formula
C20H25N7O2
Molecular Weight
395.46
Storage Conditions
-20°C
Notes
For research use only.
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