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PF-06263276

PF-06263276 is a potent and selective pan-JAK inhibitor, demonstrating IC50 values of 2.2 nM (JAK1), 23.1 nM (JAK2), 59.9 nM (JAK3), and 29.7 nM (TYK2) . This small molecule is a valuable research tool for investigating JAK/STAT signaling in autoimmune and inflammatory disease models, both in cellular and preclinical studies.

Product Specifications

CAS Number

1421502-62-6

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Smiles

CCc1cc (O) c (F) cc1-c1ccc2c (n[nH]c2c1) -c1nc2CCN (Cc2[nH]1) C (=O) c1cnc (cn1) N1CCCCC1

Molecular Formula

C31H31FN8O2

Molecular Weight

566.63

Storage Conditions

-20°C

Notes

For research use only.

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