Picrotoxinin
Picrotoxinin is a noncompetitive GABAA receptor antagonist that blocks chloride channels, exhibiting an IC50 of 1.15 μM for the α1β2γ2L subtype. This convulsant agent is widely used in neuroscience research to study inhibitory neurotransmission, synaptic plasticity, and seizure mechanisms in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
17617-45-7
Product Name Alternative
GABAA, GABA Receptor, GABAReceptor, chloride channel, Chloride channel, Chloridechannel, Picrotoxinin
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.07% (May vary between batches)
Solubility
DMSO:90 mg/mL (307.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.29 mM)
Smiles
[H][C@@]12C[C@@]3 (O) [C@]4 ([H]) [C@H] (C (C) =C) [C@@] ([H]) (OC4=O) [C@@]4 ([H]) OC (=O) [C@]1 (O2) [C@@]34C
Molecular Formula
C15H16O6
Molecular Weight
292.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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