PKF050-638
PKF050-638 is a potent and selective small molecule inhibitor of HIV-1 Rev function, exhibiting an IC50 of 0.04 μM. It acts by disrupting the CRM1-NES interaction, thereby blocking the CRM1-mediated nuclear export of Rev. This compound is a valuable research tool for studying HIV-1 replication and nucleocytoplasmic transport mechanisms in vitro.
Product Specifications
CAS Number
528893-52-9
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
C (=C\C (OCC) =O) \N1C (=NC=N1) C2=C (N) C=CC (Cl) =C2
Molecular Formula
C13H13ClN4O2
Molecular Weight
292.72
Storage Conditions
-20°C
Notes
For research use only.
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