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R121919

R121919 (NBI30775) is a potent small molecule antagonist of the corticotropin-releasing factor receptor 1 (CRF1), also exhibiting activity at the CRF2 receptor and CRF-binding proteins. Its antidepressant and anxiolytic properties make it a valuable research tool for investigating stress-related disorders in both in vitro binding assays and in vivo behavioral models.

Product Specifications

CAS Number

195055-03-9

Product Name Alternative

R 121919, R-121919, R121919, NBI 30775, NBI30775, NBI-30775, CRF2, CRF1

Field of Research

Pharmacology & Drug Discovery

Purity

99.75% (May vary between batches)

Solubility

DMSO:5 mg/mL (13.14 mM) ; Ethanol:80 mg/mL (210.23 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.63 mM)

Smiles

CCCN (CCC) c1cc (C) nc2c (c (C) nn12) -c1cnc (cc1C) N (C) C

Molecular Formula

C22H32N6

Molecular Weight

380.53

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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