RO-5963
RO-5963 is a potent small molecule dual inhibitor of the p53-MDM2 and p53-MDMX interactions, with IC50 values of approximately 17 nM and 24 nM, respectively. It is a valuable research tool for reactivating p53 function in cancer cell studies and has demonstrated efficacy in preclinical in vivo tumor models.
Product Specifications
CAS Number
1416663-77-8
Product Name Alternative
RO5963, RO-5963, RO 5963, MDMX, Mdm2, p53-MDM2, p53-MDMX, p53
Field of Research
Cell Biology, Protein Biochemistry
Purity
98.00% (May vary between batches)
Solubility
DMSO:50 mg/mL (96.36 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.36 mM)
Smiles
C (C (NC (CO) CO) =O) (N1C (=O) C (=CC=2C=3C (NC2) =C (C) C (Cl) =CC3) NC1=O) C4=CC (F) =C (F) C=C4
Molecular Formula
C24H21ClF2N4O5
Molecular Weight
518.9
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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