RO 4938581

RO 4938581 is a potent and selective GABAA α5 inverse agonist, exhibiting high affinity for α5β3γ2 receptors (Ki = 4.6 nM) with significant selectivity over α1, α2, and α3 subtypes. This compound is a valuable research tool for investigating the role of α5-containing GABAA receptors in cognitive processes, supporting both in vitro and in vivo experimental studies.