S 18986
S 18986 is an orally bioavailable, brain-penetrant positive allosteric modulator of AMPA receptors. It enhances cognition in rodent models by potentiating glutamatergic signaling and increasing hippocampal acetylcholine and noradrenaline release, as demonstrated in object recognition memory tests.
Product Specifications
CAS Number
175340-20-2
Product Name Alternative
AMPA, S 18986, S18986, S-18986
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.25% (May vary between batches)
Solubility
DMSO:60 mg/mL (267.52 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (11.15 mM)
Smiles
O=S1 (=O) C=2C (N3[C@@] (N1) (CCC3) [H]) =CC=CC2
Molecular Formula
C10H12N2O2S
Molecular Weight
224.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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