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S 18986

S 18986 is an orally bioavailable, brain-penetrant positive allosteric modulator of AMPA receptors. It enhances cognition in rodent models by potentiating glutamatergic signaling and increasing hippocampal acetylcholine and noradrenaline release, as demonstrated in object recognition memory tests.

Product Specifications

CAS Number

175340-20-2

Product Name Alternative

AMPA, S 18986, S18986, S-18986

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Purity

99.25% (May vary between batches)

Solubility

DMSO:60 mg/mL (267.52 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (11.15 mM)

Smiles

O=S1 (=O) C=2C (N3[C@@] (N1) (CCC3) [H]) =CC=CC2

Molecular Formula

C10H12N2O2S

Molecular Weight

224.28

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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