SCH28080
SCH28080 is a reversible, potassium-competitive inhibitor of gastric H+/K+-ATPase, exhibiting potent anti-secretory and cytoprotective effects. With an IC50 of 20 nM in rabbit microsomal assays, it demonstrates significant anti-ulcer activity in vivo, making it a valuable research tool for studying gastric acid secretion and gastrointestinal pharmacology.
Product Specifications
CAS Number
76081-98-6
Product Name Alternative
H+/K+-ATPase, H+/K+-ATPase, rabbit microsomal membranes, SCH 28080, SCH28080, SCH-28080, Proton pump, Protonpump
Field of Research
Pharmacology & Drug Discovery
Purity
97.12% (May vary between batches)
Solubility
DMSO:90 mg/mL (324.53 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.9 mM)
Smiles
Cc1nc2c (OCc3ccccc3) cccn2c1CC#N
Molecular Formula
C17H15N3O
Molecular Weight
277.32
Storage Conditions
-20°C
Notes
For research use only.
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